In order to investigate the normal immunological standard and its change of HIV infected persons in Korea, we had tested 140 HIV seronegative and 113 HIV seropositive persons for a period of 2.5 years. The absolute CD+ T cell count and its
percentage in
lymphocyte for the normal subject of Koran were measured and found to be 882±246/μl, 32.92±2.00%, respectively. Although the course of HIV infection may vary among the individual patients, a common pattern of its pathophysiological development
has
been recognized by counting CD4+ T cells as a prognostic marker. Those individuals with absolute CD4+ T count of more than 500, who belong to the early infected group, initially showed dramatic decline in CD+ T cell count (-94/6 month) and
thereafter
mild decrease when it comes down to 5 hundreds (-43/6 month). The group with absolute CD+ T cell counts of 351-500 showed even milder decrease (-11.3/6 month), during which the clear difference in the decline rate can be observed between the
groups
with/without the treatment of red ginseng and AZT. The period taken for the AIDS development from the initial infection is insignificant, but estimated 10 years on the average. The studies on the immunological decline of HIV infected persons as
well as
the normal immunological standard of Korean is expected to be used as a basis for the prevention and treatment of opportunistic infection.
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